CAS200 System (~ 1984)
The CAS200 System measured DNA Ploidy and Immunohistochemistry stain intensity for markers such as Estrogen Receptors, Progesterone Receptors, and HER2/neu. The new test procedures introduced quantitative stoichiometric densitometry as a routine procedure in pathology, with a full complement of calibration material and specialized stains. The CAS200 was sold worldwide by Cell Analysis Systems in the mid 1980's, and later by Becton Dickinson in the early 1990's.
Bacus Labs was the first to commercialize DNA ploidy for image cytometry with the CAS200 System. This test was widely accepted after its introduction and is still in use in many institutions, more than 20 years later. The DNA Ploidy test is commonly performed in many suspected cancer cases.
For immunohistochemistry stain quantitation the CAS200 used a patented dual wavelength, narrow bandwidth optical system to isolate two-component stains as markers. Measurements of Estrogen receptors, Progesterone receptors and Her2/neu are also now commonly performed in breast cancer diagnosis.