James W. Bacus, Ph.D.


1.        Bacus, J.W. and Gose, E.E.: Leukocyte Pattern Recognition. IEEE Trans. on Sys, Man and Cybernet. SMC‑2 (4), 513‑526, 1972.

2.        Bacus, J.W.: The Observer Error in Peripheral Blood Cell Classification. Am. J. Clin Path. 59: (2), 223‑230, 1973.

3.       Bacus, J.W.: Erythrocyte Morphology and Centrifugal "Spinner" Blood Film Preparations, J. Histochem. Cytochem. 22:506‑516, 1974.

4.        Bacus, J.W.:  A Whitening Transformation for Two‑Color Blood Cell Images.  Pattern Recognition, 8:53‑60, 1976.

5.        Mui, J.K., Fu, K.S. and Bacus, J.W.:  Automated Classification of Blood Cell NeutrophilsJ. Histochem. Cytochem. 25:633‑640, 1977.

6.        Yasnoff, W.A., Mui, J.K. and Bacus, J.W.:  Error Measures for Scene Segmentation.  Pattern Recognition, 9:217‑231, 1977.

7.        Bacus, J.W.:  The Development of Automated Differential Systems, in Proceedings of the CAP Conference on Differential White Cell Counting, published by College of American Pathologists, 1979.

8.        Belanger, M.G., Yasnoff, W.A., Penn, R.D. and Bacus, J.W.:  Automated Scene Analysis of CT Scans.  Comput. Tomogr. 3:201‑211, 1979.

9.        Trobaugh, F.E. and Bacus, J.W.:  Design and Performance of the LARC Automated Leukocyte Classified, in Proceedings of the CAP Conference on Differential White Cell Counting, published by College of American Pathologists, 1979.

10.      Yasnoff, W.A., Galbraith, W. and Bacus, J.W.:  Error Measures for Objective Assessment of Scene Segmentation Algorithms.  Anal. Quant. Cytol. 1:107‑121, 1979.

11.       Galbraith, W., Marshall, P.N., Lee, E.S. and Bacus, J.W.:  Studies on Papanicolaou Staining.  I. Visible‑Light Spectra of Stained Cervical Cells. Anal. Quant. Cytol. 1:160‑168, 1979.

12.       Marshall, P.N., Galbraith, W. and Bacus, J.W.:  Studies on Papanicolaou Staining.  II. Quantitation of Dye Components Bound by Cervical Cells.  Anal. Quant. Cytol. 1:169‑178, 1979.

13.       Bacus, J.W., Watt, W., Trobaugh, Jr., F.E.:  Clinical Evaluation of a New Electrical Impedance Instrument for Counting Platelets in Whole Blood, Am. J. Clin. Pathol. 73:655‑663, 1980.

14.       Bacus, J.W.:  Automation of Morphology in Hematology.  In Handbook Series in Clinical Laboratory Science:  Section I:  Hematology Vol. II, R.M. Schmidt, ed., CRC Press, Inc., 79‑87, 1980.

15.       Bacus, J.W.:  Quantitative Measurement of Red Blood Cell Central Pallor and HypochromasiaAnal. Quant. Cytol. 2:123‑130, 1980.

16.       Bacus, J.W.:  Quantitative Morphological Analysis of Red Blood Cells. Blood Cells, 6:295‑314, 1980.

17.      Westerman, M., O'Donnell, J. and Bacus, J.W.:  Assessment of the Anemia of Chronic Disease by Digital Image Processing of Red Cells.  Am. J. Clin. Path. 74:163‑166, 1980.

18.       Marshall, P.N., Galbraith, W., Navarro, E.F. and Bacus, J.W.:  Microspectrophotometric Studies of Romanowsky Stained Blood Cells:  II.  Comparison of the Performance of Two Standardized Stains.  J. of Microsc., 124:197‑210, 1981.

19.      Bacus, J.W.:  Digital Image Processing Measurements of Red Blood Cell Size and Hemaglobin Content.  In Advances in Hematological Methods:  The Blood Count., ed. O.W. vanAssendelft and J.M. England, CRC Press, Inc., 1982.

20.      Westerman, M.P., Bacus, J.W.:  Red Blood Cell Morphology in Sickle Cell Anemia as Determined by Image Processing Analysis:  The Relationship of Painful Crises.  Am. Jo. Clin. Path., 79:667‑672, 1983.

21.      Bacus, J.W., Wiley, E. L., Galbraith, W., Marshall, P. N., Wilbanks, G.D. and Weinstein, R.S.: Malignant Cell Detection and Cervical Cancer Screening. Anal. Quant. Cytol. 6:121‑130, 1984.

22.      Bacus, J.W.:  Quantitative Red Cell Morphology.  Survey and Synthesis of Pathology Research,symposium on Cell Image Analysis. Monog. Clin. Cytol. 9:1‑27, publisher Karger, Basel, 1984.

23.      Yasnoff, W.A. and Bacus, J.W.:  Scene Segmentation Algorithm Development Using Error Measures.  Anal. Quant. Cytol. 6:45‑58, 1984.

24.       Penn, R.D. and Bacus, J.W.:  The Brain as a Sponge:  A Computed Tomographic look at Hakim's Hypothesis.  Neurosurgery 14:670‑675,1984.

25.      Bacus, J.W.:  Cytometric Approaches to Red Blood Cells.  Pure & Appl. Chem. 57:593, 1985.

26.      Bacus, J.W., Grace L.J.: Optical Microscope System for Standardized Cell Measurements and Analyses.  Applied Optics, 26: No. 16, 3280‑3293, 1987.

27.      Bacus, S., Flowers, J., Press, M., Bacus, J.W., McCarty,K. :  Evaluation of Estrogen Recepter in Primary Breast Carcinoma by Computer Assisted‑Image Analysis. Am Journal of Clinical Pathology,90: No. 3, 233‑239, 1988.

28.       Bacus, S., Goldschmidt, R., Chin, D., Moran, G., Weinberg, D., Bacus, J.W., Biological Grading of Breast Cancer Using Antibodies to Proliferating Cells and Other Markers. Am.Journal of Pathology, 135: No. 5, 783‑792, 1989.

29.       Gurley A.M., Hidvegi D.F., Bacus J.W., Bacus S.S.:  Comparison of the Papanicolaou and Feulgen Staining Methods for DNA Quantification by Image Analysis.  Cytometry  11:468‑474, 1990.

30.       Dawson AE, Cibas ES, Bacus JW, Weinberg DS.  Chromatin texture measurement by Markovian analysis.  Anal Quant Cytol Histol. 15:227‑235, 1993.

31.       Bacus J.W., Bacus J.V.: A Method of Correcting DNA Ploidy Measurements in Tissue Sections. Modern Pathology 7: No6 562‑664, 1994.

32.       Bacus J.W., Bacus J.V.: Quality Control in Image Cytometry. J. Cellular Biochem (Supp) 19:153‑164, 1994.

33.       Bacus J.W., Hernicz, R.S., Bacus J.V.: Dual Wavelength Imaging Microdensitometry for Immunocytochemical Assays in Microscopy. SPIE Proceedings Series, Vol 2622:704‑710, 1995.

34.      Bacus J.W.: Cervical Cell Recognition and Morphometric Grading by Image Analysis. J.   Cellular Biochem(Supp) 23:33‑42, 1995.

35.       Boone C.W., Bacus J.W., Bacus J.V., Steele V.E. Kelloff G.J: Properties of Intraepithelial  Neoplasia Relevant to Cancer Chemoprevention and to the Development of  Surrogate End Points for Clinical Trials. Soc, Exp. Biol. Med. 216:151-165, 1997.

36.      Bacus J.W., Bacus J.V. Stoner G.D., Moon R.C., Kelloff G.J., Boone C.W.: Quantitation of Preinvasive Neoplastic Progression in Animal Models of Chemical Carcinogenesis. J.  Cellular Biochem (Supp) 1998.

37.       Bacus J W; Boone C W; Bacus J V; Follen M; Kelloff G J; Kagan V; Lippman S M. Image morphometric nuclear grading of intraepithelial neoplastic lesions with applications to cancer chemoprevention trials.  Cancer Epidemiology, Biomarkers & Prevention 1999;8 (12):1087-94.

39.       Boone C W; Stoner G D; Bacus J V; Kagan V; Morse M A; Kelloff G J; Bacus J WQuantitative grading of rat esophageal carcinogenesis using computer-assisted image tile analysis.  Cancer epidemiology, biomarkers & prevention : 2000;9(5):495-500.

40.       Boone C W; Stoner G D; Bacus J V; Kagan V; Morse M A; Kelloff G J; Bacus J W: Chemoprevention with theaflavins of rat esophageal intraepithelial neoplasia quantitatively monitored by image tile analysis.  Cancer Epidemiology, Biomarkers & Prevention: 2000;9(11):1149-54.

41.       Boone C W; Lieberman R; Mairinger T; Palcic B; Bacus J; Bartels P; Computer-assisted image analysis-derived intermediate endpoints.  Urology 2001;57(4 Suppl 1):129-31.

42.       Alvarez Ronald D; Conner Michael G; Weiss Heidi; Klug Patricia M; Niwas Santosh; Manne Upender; Bacus James; Kagan Valeriy; Sexton Katherine C; Grubbs Clinton J; Isam-Eldin; Grizzle William E: The efficacy of 9-cis-retinoic acid (aliretinoin) as a chemopreventive agent for cervical dysplasia: results of a randomized double-blind clinical trial. Cancer Epidemiology, Biomarkers & Prevention:2003; 12(2):114-9.

Special Publications:

1.        Bacus, J.W., et al: Reference Procedure for the Quantitative Determination of Hemoglobin in Blood.  National Committee for Clinical Laboratory Standards,Subcommittee on Quantitative Cellular Hematology, October, 1982.

2.        Bacus, J.W., et al:  Reference Procedure for the Determination of Packed Cell Volume by the Microhematocrit Method.  National Committee for Clinical Laboratory Standards,  Subcommittee on Quantitative Cellular Hematology, November, 1982.