Neoplastic Progression
The figure above shows the development of neoplasia from a precursor state to "intraepithelial neoplasia" and then finally to an invasive neoplasia. Bacus Laboratories developed methods to measure intraepithelial neoplasia, i.e. measurements that quantitate the development of the neoplastic process before it becomes metastatic. This is described in "Bacus J W; Bacus J V; Stoner G D; Moon R C; Kelloff G J; Boone C W. Quantitation of preinvasive neoplastic progression in animal models of chemical carcinogenesis. Journal of Cellular Biochemistry Supplement (28-29):21-38, 1997", and in "Bacus, J.W., Bacus J.V.: Method and Apparatus for Testing a Progression of Neoplasia Including cancer Chemoprevention Testing. U.S. Patent 6,031,930. 2000".